Acute muscle spasms, as an adjunct to rest and physical therapy.
Adults:
≥15yrs: initially 5mg 3 times daily, may increase to 7.5mg or 10mg 3 times daily; max 2–3 weeks. Elderly or hepatic impairment: consider less frequent dosing.
Children:
<15yrs: not recommended.
Contraindications:
During or within 14 days of MAOIs. Acute post-MI. Arrhythmias, heart block, other conduction disturbances. CHF. Hyperthyroidism.
Precautions:
Hepatic impairment (if moderate to severe: not recommended). Urinary retention. Angle-closure glaucoma. Increased intraocular pressure. Elderly. Pregnancy (Cat.B). Nursing mothers.
Interactions:
See Contraindications. Hypertensive crisis with MAOIs. Potentiates anticholinergics, alcohol, other CNS depressants. May antagonize guanethidine, clonidine. Tramadol increases seizure risk.